PomBase

Submitted by Valerie Wood on Wed, 12/16/2020 - 12:59

PomBase is a comprehensive Model Organism DataBase (MOD) database for the fission yeast Schizosaccharomyces pombe (S. pombe or fission yeast). Fission yeast is a eukaryotic model species used to study many cell biological processes relevant to humans (for example: cytokinesis, DNA replication, cell cycle, gene expression, membrane biology,  and chromosome segregation).  Over 75% of its 5000 proteins are conserved to human, mainly those which are critical to maintaining a single cell. Over 1400  of these proteins are known to be causal for inherited diseases in human.  PomBase provides functional annotation, literature curation and access to large-scale data sets. We collaborate with many other MODs (mainly U.S. based)  to create data standards (e.g. semantic standardization of thousands of biological concepts) that can be used across species (working with the Gene Ontology Consortium, the Monarch Initiative,  and uPHENO project). We also create tools to enable standardized curation and have launched a successful community curation initiative to enable researchers to curate their own published research into these databases. Finally, we focus on annotation breadth (ensuring all proteins where possible are annotated, and through this work, we identify those proteins which remain unstudied in any species (aka "unknown proteins").

Disciplines

Biological Sciences, Health & Food
E-Infrastructure & Data
Keywords
database
molecular biology
model organism
biocuration
curation
ontologies
genetics

 

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Public Contact email
vw253@cam.ac.uk
Telephone Number

+441223746961

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Sanger Building, Tennis Court Rd
East of England
CB2 1GA
United Kingdom

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