The National Phenome Centre, initially funded by a 5 year grant from the Medical Research Council (MRC) and the National Institute for Health Research (NIHR) and led by Imperial College London and King’s College London, was founded in 2012 to deliver access to a world-class capability in metabolic phenotyping, to benefit the whole UK translational medicine community.
The Centre’s establishment enables us to take advantage of an unprecedented opportunity offered by the legacy of the 2012 Olympics state-of-the-art drug testing/analytical laboratory. The NPC combines the power of both 600Mhz NMR spectrometers and ultra-high performance liquid chromatography to create a state-of-the-art metabolic phenotyping facility which is able to offer access to instrumentation and expertise to allow the generation of high-quality metabolic profiling and targeted assay data utilising our publish protocols and open-source informatics pipelines. The NPC is able to offer support to both specialist metabolomics researchers as well as those with limited experience, providing insight into study design, assay suitability, assay development, data generation and large-scale and specialised data analysis. The Centre has the ability to analyse many thousands of samples from projects varying in size from 10s to 1000s of samples. Our collaborative ethos to support the provision of metabolic profiling to researchers no matter what disease area or level of knowledge is a key tenant of the Centre to support the identification of targets to support the goal of stratified medicine and precision medicine. The National Phenome Centre is one of two Phenome Centres in the UK.
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