Bristol Bioimaging is a collection of major research facilities which uniquely supports multimodal imaging from quasi-atomic to organismal level (animals and humans). This collection of facilities advances our understanding from fundamental biomolecular level to whole body function The imaging facilities provide vital infrastructure support for a diverse range of research projects from around 200 research groups, encompassing synthetic, cell and organismal biology in the context of animal, plant and human biology and medicine. As such it provides a unique pipeline from discovery through to translational science, including testing of medical interventions. The facilities support projects across multiple faculties within Bristol University and are open to access by researchers from other universities and businesses, collaborating with >20 Universities and >10 companies. Each facility provides a bespoke service ranging from technical support for experimental design, image acquisition and analysis through a dedicated technical team guided by an academic director. The facilities share best practice and collaborate on projects requiring access to multiple imaging modes. Bristol Bioimaging also interacts closely with other imaging facilities in Bristol, for example those offering microscopy (AFM and EM) for chemistry and materials research. The range of technology available through Bristol Biomedical Imaging is best summarized for each consortium member: • GW4 cryo-EM: High-resolution cryo-EM for single particle analysis and tomography. Main application: Structural analysis of large macromolecular complexes. • Wolfson Bioimaging Facility: Advanced light and electron microscopy with 27 microscopes (confocal, widefield, multiphoton, lightsheet, super-resolution, TIRF, FLIM, high content screening, TEM, SEM, SBF-SEM). Applications include imaging and analysis of cell ultrastructure, protein complexes, nanomaterials, live cells, tissues and small organisms (Drosophilla, Zebrafish, mice). • Translational Biomedical Research Centre: A 3T MRI scanner, floor mounted x-ray Cath lab, advanced cardiovascular eco-doppler, and Optical coherence tomography. A MicroPET/CT housed at PETIC (Cardiff) focuses on small rodent in-vivo imaging. • Clinical Research and Imaging Centre: A full body 3T MRI scanner with physiological monitoring, associated sleep labs, ultrasound scanner, neuropsychological and video monitoring equipment.
Biological Sciences, Health & Food
E-Infrastructure & Data
Physical Sciences & Engineering
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